![]() Altogether, these findings indicate that col is required in at least two distinct programs that control the morphological and sensory specificity of Drosophila md neurons. The ddaC neuron is colored red (top row of cells), the v ada neuron is colored blue, and the vdaB neuron is. Characterisation of the col upstream region identified a 9-kb cis-regulatory region driving col expression in all class IV md neurons, even though these originate from two types of sensory precursor cells. A schematic of the arrangement of class IV neurons. Col is also required for the class IV da-specific expression of pickpocket (ppk), which encodes a degenerin/epithelial sodium channel subunit required for larval locomotion. Drosophila dendritic arborization (da) neurons of the class IV type are sensory neurons with extensive dendritic arbors that cover the body wall of the animal and are required for thermal (), light (), and mechanical sensation (79). Col control on dendrite branching is distinct from that exerted by Cut, another transcription factor expressed in class IV neurons and necessary for proper dendrite morphogenesis. Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting. Nevertheless, these examples show that the model is versatile and has predictive potential beyond just Drosophila class IV sensory neurons. When lacking Col activity, class IV da neurons are formed but display a reduced dendrite arborisation. Drosophila type II neuroblasts (NBs, Drosophila. Here, we report that Collier/Knot (Col/Kn), the Drosophila member of the COE family of transcription factors, is transiently expressed in the subset of multidendritic arborisation (da) sensory neurons that display an highly branched dendritic arborisation, class IV neurons. The highly stereotyped organisation of the Drosophila peripheral nervous system (PNS) provides a model to study neuronal determination and morphogenesis. da neurons have polarized neurites, with axons and dendrites leaving from opposite sides of the soma. One neuronal subtype, called the dendritic arborization (da) neuron, spreads complex dendrites to cover the body wall (Fig. Proper sampling of sensory inputs critically depends upon neuron morphogenesis and expression of sensory channels. Sensory neurons in the Drosophila embryo and larva cover the body wall and subserve different sensory functions.
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